SAM D21 Arm® Cortex®-M0+ Microcontrollers

Microchip Technology SAM D21 Arm® Cortex®-M0+ Microcontrollers (MCUs) are low-power MCUs that range from 32- to 64-pins with up to 256KB Flash and 32KB of SRAM. The Microchip Technology SAM D21 MCUs have a maximum 48MHz frequency and reach 2.46 CoreMark/MHz. The devices are designed for simple and intuitive migration with identical peripheral modules. Features include hex-compatible code, identical linear address map, and pin-compatible migration paths between all devices in the product series. All devices include intelligent and flexible peripherals, an Event System for inter-peripheral signaling, and support for capacitive touch buttons, slider, and wheel user interfaces.

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Description Datasheet Availability Pricing (USD) Filter the results in the table by unit price based on your quantity.
Qty. RoHS ECAD Model Series
Mounting Style
Package/Case
Core
Program Memory Size
Data Bus Width
ADC Resolution
Maximum Clock Frequency
Number of I/Os
Data RAM Size
Supply Voltage - Min
Supply Voltage - Max
Minimum Operating Temperature
Maximum Operating Temperature
Qualification
Packaging

Microchip Technology ARM Microcontrollers - MCU CMO,TQFP32,Ligthing,128KFlash,Trays, Extended temp
Datasheet
250In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-32 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 26 I/O 16 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU CMO,QFN32,Ligthing,128KFlash,Trays, 105 C
Datasheet
30In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT VQFN-32 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 26 I/O 16 kB 1.62 V 3.63 V - 40 C + 105 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 32QFN 125C, GREEN,1.6-3.6V,48MHz
Datasheet
119In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 256 kB 32 bit 12 bit 48 MHz 26 I/O 32 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 48QFN,85C TEMP, GREEN, 3.3V, 48MHZ
Datasheet
109In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT QFN-48 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 38 I/O 8 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU CM0, TQFP 48 , 128KFlash, USB, Extended Temp 125C, Tray
Datasheet
106In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-48 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 38 I/O 16 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU CM0,TQFP48, 128kFlash,Trays,USB, I Temp
Datasheet
14In Stock
2,000On Order
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-48 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 38 I/O 16 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU CM0, TQFP 64 , 128KFlash, USB, Extended Temp 125C, Tray
Datasheet
186In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-64 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 52 I/O 16 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 128KB 16KB32QFN GRN1.6-3.6V48MHz
Datasheet
323In Stock
490Expected 2026/10/08
Min.: 1
Mult.: 1

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 26 I/O 16 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 48TQFP,125C TEMP, GREEN, 3.3V, 48MHZ
Datasheet
46In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-48 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 38 I/O 8 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 48TQFP,125C TEMP, GREEN, 3.3V, 48MHZ,T&R
Datasheet
102In Stock
MouseReel Available
Min.: 1
Mult.: 1
: 2,500

SAMD21 SMD/SMT TQFP-48 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 38 I/O 8 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Reel, Cut Tape, MouseReel
Microchip Technology ARM Microcontrollers - MCU 128KB 16KB 48QFN GRN1.6-3.6V48MHz
Datasheet
140In Stock
4,000Expected 2026/09/29
MouseReel Available
Min.: 1
Mult.: 1
: 4,000

SAMD21 SMD/SMT QFN-48 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 38 I/O 16 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Reel, Cut Tape, MouseReel
Microchip Technology ARM Microcontrollers - MCU 64TQFP 125C, GREEN,1.6-3.6V,48MHz
Datasheet
318In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-64 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 52 I/O 16 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 128KB 16KB 64TQFP GRN1.6-3.6V48MHz
Datasheet
25In Stock
MouseReel Available
Min.: 1
Mult.: 1
: 1,500

SAMD21 SMD/SMT TQFP-64 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 52 I/O 16 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Reel, Cut Tape, MouseReel

Microchip Technology ARM Microcontrollers - MCU 64QFN 125C, GREEN,1.6-3.6V,48MHz
Datasheet
226In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT QFN-64 ARM Cortex M0+ 256 kB 32 bit 12 bit 48 MHz 52 I/O 32 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 48TQFP,85C TEMP, GREEN, 3.3V, 48MHZ
Datasheet
293In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT TQFP-48 ARM Cortex M0+ 32 kB 32 bit 12 bit 48 MHz 38 I/O 4 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU CMO,QFN48,Ligthing,128KFlash,Trays, 105 C
Datasheet
237In Stock
Min.: 1
Mult.: 1

SAMD21 SMD/SMT VQFN-48 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 38 I/O 16 kB 1.62 V 3.63 V - 40 C + 105 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 128KB 16KB32QFN GRN1.6-3.6V48MHz
Datasheet
8,529Expected 2026/09/29
MouseReel Available
Min.: 1
Mult.: 1
: 5,000

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 26 I/O 16 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Reel, Cut Tape, MouseReel
Microchip Technology ARM Microcontrollers - MCU 256KB 32KB 48QFN GRN1.6-3.6V48MHz
Datasheet
2,739On Order
Min.: 1
Mult.: 1

SAMD21 SMD/SMT QFN-48 ARM Cortex M0+ 256 kB 32 bit 12 bit 48 MHz 38 I/O 32 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 256KB 32KB 64TQFP GRN1.6-3.6V48MHz
Datasheet
2,724Expected 2026/10/01
MouseReel Available
Min.: 1
Mult.: 1
: 1,500

SAMD21 SMD/SMT TQFP-64 ARM Cortex M0+ 256 kB 32 bit 12 bit 48 MHz 52 I/O 32 kB 1.62 V 3.63 V - 40 C + 85 C AEC-Q100 Reel, Cut Tape, MouseReel
Microchip Technology ARM Microcontrollers - MCU 32TQFP,125C TEMP, GREEN, 3.3V, 48MHZ
Datasheet
Non-Stocked Lead-Time 10 Weeks
Min.: 500
Mult.: 250

SAMD21 SMD/SMT TQFP-32 ARM Cortex M0+ 32 kB 32 bit 12 bit 48 MHz 26 I/O 4 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 32QFN 105C, GREEN,1.6-3.6V,48MHz,T&R
Datasheet
Non-Stocked Lead-Time 12 Weeks
Min.: 5,000
Mult.: 5,000
: 5,000

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 32 kB 32 bit 12 bit 48 MHz 26 I/O 4 kB 1.62 V 3.63 V - 40 C + 105 C AEC-Q100 Reel
Microchip Technology ARM Microcontrollers - MCU 32TQFP,125C TEMP, GREEN, 3.3V, 48MHZ
Datasheet
Non-Stocked Lead-Time 10 Weeks
Min.: 500
Mult.: 250

SAMD21 SMD/SMT TQFP-32 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 26 I/O 8 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 32QFN 125C, GREEN,1.6-3.6V,48MHz
Datasheet
Non-Stocked Lead-Time 12 Weeks
Min.: 490
Mult.: 490

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 26 I/O 8 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Tray
Microchip Technology ARM Microcontrollers - MCU 32QFN 105C, GREEN,1.6-3.6V,48MHz,T&R
Datasheet
Non-Stocked Lead-Time 10 Weeks
Min.: 5,000
Mult.: 5,000
: 5,000

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 64 kB 32 bit 12 bit 48 MHz 26 I/O 8 kB 1.62 V 3.63 V - 40 C + 105 C AEC-Q100 Reel
Microchip Technology ARM Microcontrollers - MCU 32QFN 125C, GREEN,1.6-3.6V,48MHz
Datasheet
Non-Stocked Lead-Time 10 Weeks
Min.: 5,000
Mult.: 5,000
: 5,000

SAMD21 SMD/SMT QFN-32 ARM Cortex M0+ 128 kB 32 bit 12 bit 48 MHz 26 I/O 16 kB 1.62 V 3.63 V - 40 C + 125 C AEC-Q100 Reel